Paper 1, Section II, J
A clinical study follows a number of patients with an illness. Let be the length of time that patient lives and a vector of predictors, for . We shall assume that are independent. Let and be the probability density function and cumulative distribution function, respectively, of . The hazard function is defined as
We shall assume that , where is a vector of coefficients and is some fixed hazard function.
(a) Prove that .
(b) Using the equation in part (a), write the log-likelihood function for in terms of and only.
(c) Show that the maximum likelihood estimate of can be obtained through a surrogate Poisson generalised linear model with an offset.
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